Breast Cancer: Comparative Effectiveness of Positron Emission Mammography and MR Imaging in Presurgical Planning for the Ipsilateral Breast

Breast Cancer: Comparative Effectiveness of Positron Emission Mammography and MR Imaging in Presurgical Planning for the Ipsilateral Breast
Wendie A. Berg, Kathleen S. Madsen, Kathy Schilling, Marie Tartar, Etta D. Pisano, Linda Hovanessian Larsen, Deepa Narayanan, Al Ozonoff, Joel P. Miller, and Judith E. Kalinyak
Radiology 2011; 258 59-72

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Overall, 61 (16%) of 388 participants had an appropriate change in surgical management based on MR findings--more than the 41 (11%) participants with an appropriate change based on positron emission mammography (PEM) findings (P =. 003) and fewer than the 71 (18%) participants with an appropriate change based on combined PEM and MR findings (P =. 004 for comparison with MR imaging alone) ; 25 (6.4%) women had excessive excisions on the basis of MR findings compared with 19 (4.9%) women who had them on the basis of PEM findings (P =. 26) and 32 (8.2%) women who had them after undergoing combined PEM and MR imaging (P =. 023 for comparison with MR imaging alone)

Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer

Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer
Yanming Yu, Quan Jiang, Yanwei Miao, Jun Li, Shanglian Bao, Haoyu Wang, Chunxue Wu, Xiaoying Wang, Jiong Zhu, Yi Zhong, E. Mark Haacke, and Jiani Hu
Radiology 2010;257 47-55

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A quantitative dynamic contrast-enhanced MR imaging method has been developed to assess treatment response to neoadjuvant chemotherapy in patients with breast cancer by using standard clinical dynamic contrast-enhanced MR imaging data without measuring either arterial input function or baseline T1.

Results of the simulation study demonstrate that the T1-FCM method appears to be relatively insensitive to noisy dynamic contrast-enhanced MR imaging data. This method could prove useful in the evaluation of breast cancer therapy

Diffusion-weighted MR Imaging: Pretreatment Prediction of Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer

Diffusion-weighted MR Imaging: Pretreatment Prediction of Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer
Sang Hee Park, Woo Kyung Moon, Nariya Cho, In Chan Song, Jung Min Chang, In-Ae Park, Wonshik Han, and Dong-Young Noh
Radiology 2010;257 56-63


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Our results show that in patients with breast cancer, the pretreatment apparent diffusion coefficients of patients who responded to neoadjuvant chemotherapy are significantly lower than those of patients who did not respond to neoadjuvant chemotherapy.

Patients with breast cancer and a low pretreatment ADC tended to respond better to chemotherapy. Prediction of response to neoadjuvant chemotherapy with DW MR imaging might help physicians individualize treatments and avoid ineffective chemotherapy

Short-term Follow-up Recommendations after Preoperative Breast MR Assessment for Breast Cancer Diagnosis: Are We Lacking a Rational Basis?

Short-term Follow-up Recommendations after Preoperative Breast MR Assessment for Breast Cancer Diagnosis: Are We Lacking a Rational Basis?
R. James Brenner
Radiology 2010;257 18-21

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Unless clinical studies demonstrate previously unrecognized changes on serial MR imaging studies under such circumstances which likely are not based on the mechanisms of actions described earlier, the recommendation for short-term follow-up MR imaging after preoperative assessment should be reconsidered

Why Do Purely Intraductal Cancers Enhance on Breast MR Images?
Christiane K. Kuhl
Radiology 2009;253 281-283

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Diagnosis and treatment of high-grade DCIS can be considered primary prevention of high-grade invasive cancer.

Thus, we have reason to assume that screening with MR imaging would offer a mortality benefit that is higher than that achieved with mammographic screening, not only because of the higher overall sensitivity offered by MR imaging but also because of its bias for selectively depicting prognostically relevant disease

On the basis of the results of the animal study performed by Jansen et al and clinical observations, there is compelling evidence to suggest that the imaging phenotype of a ductal carcinoma in situ (DCIS) lesion (its detectability at mammography and MR imaging, specifically the presence or absence of calcifications on mammograms and the presence or absence of calcifications and the degree of their enhancement on MR images) conveys important biologic information that will be useful when guiding DCIS treatment.

Diffusion-weighted MR for Differentiation of Breast Lesions at 3.0 T: How Does Selection of Diffusion Protocols Affect Diagnosis?

Diffusion-weighted MR for Differentiation of Breast Lesions at 3.0 T: How Does Selection of Diffusion Protocols Affect Diagnosis?
Wolfgang Bogner, Stephan Gruber, Katja Pinker, Günther Grabner, Andreas Stadlbauer, Michael Weber, Ewald Moser, Thomas H. Helbich, and Siegfried Trattnig
Radiology 2009;253 341-351

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Optimum ADC determination and DW imaging quality at 3.0 T was found with a combined b value protocol of 50 and 850 sec/mm2. This provided a high accuracy for differentiation of benign and malignant breast tumors

Standardization of b values allows improved inter-study comparisons on the diagnostic accuracy of diffusion-weighted MR breast examinations

Cancers in BRCA1 and BRCA2 Carriers and in Women at High Risk for Breast Cancer: MR Imaging and Mammographic Features

Cancers in BRCA1 and BRCA2 Carriers and in Women at High Risk for Breast Cancer: MR Imaging and Mammographic Features
Fiona J. Gilbert, Ruth M. L. Warren, Gek Kwan-Lim, Deborah J. Thompson, Ros A. Eeles, D. Gareth Evans, Martin O. Leach, and For the United Kingdom Magnetic Resonance Imaging in Breast Screening (MARIBS) Study Group
Radiology 2009;252 358-368
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Our review of the images from prior MR imaging examinations shows that the cancers grow in size and that enhancement curves change from type 1 to type 2 or 3 and demonstrate greater signal enhancement over time

Predicting Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer by Using MR Imaging and Quantitative 1H MR Spectroscopy

Predicting Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer by Using MR Imaging and Quantitative 1H MR Spectroscopy
Hyeon-Man Baek, Jeon-Hor Chen, Ke Nie, Hon J. Yu, Shadfar Bahri, Rita S. Mehta, Orhan Nalcioglu, and Min-Ying Su
Radiology 2009;251 653-662

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The study results suggest that when the reduction in choline-containing compounds was higher than the reduction in tumor size, the tumor was more likely to achieve pathologic complete response

Triple-Negative Breast Cancer: Correlation between MR Imaging and Pathologic Findings

Triple-Negative Breast Cancer: Correlation between MR Imaging and Pathologic Findings
Takayoshi Uematsu, Masako Kasami, and Sachiko Yuen
Radiology 2009;250 638-647

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MR imaging findings of a unifocal lesion, mass lesion type, smooth mass margin, heterogeneous rim enhancement, persistent enhancement pattern, and very high signal intensity on T2-weighted images can be used to detect triple-negative breast cancer

Tumor Blood Flow with Human Epidermal Growth Factor Receptor 2 Status and Clinicopathologic Findings--Preliminary Results

econvolution-based Dynamic Contrast-enhanced MR Imaging of Breast Tumors: Correlation of Tumor Blood Flow with Human Epidermal Growth Factor Receptor 2 Status and Clinicopathologic Findings--Preliminary Results
Smitha Makkat, Robert Luypaert, Tadeusz Stadnik, Claire Bourgain, Steven Sourbron, Martine Dujardin, Jacques De Greve, and Johan De Mey
Radiology 2008;249 471-482

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To our knowledge, we are the first to examine the association of model-independent MR-derived tumor blood flow, which is a simple and physiologically straightforward parameter, with clinicopathologic characteristics of prognosis, including human epidermal growth factor receptor 2 status

Direct MR Galactography: Feasibility Study

Direct MR Galactography: Feasibility Study
Siegfried A. Schwab, Michael Uder, Rudiger Schulz-Wendtland, Werner A. Bautz, Rolf Janka, and Evelyn Wenkel
Radiology 2008;249 54-61

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Direct MR galactography combined with MR imaging may provide more diagnostic information than conventional galactography in patients with pathologic nipple discharge because it can show both ductal morphology and the extent of disease before surgery

Invasive Breast Cancer: Predicting Disease Recurrence by Using High-Spatial-Resolution Signal Enhancement Ratio Imaging

Invasive Breast Cancer: Predicting Disease Recurrence by Using High-Spatial-Resolution Signal Enhancement Ratio Imaging
Ka-Loh Li, Savannah C. Partridge, Bonnie N. Joe, Jessica E. Gibbs, Ying Lu, Laura J. Esserman, and Nola M. Hylton
Radiology 2008;248 79-87

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Our study results demonstrate that the size of tumor volume segmented by using set ranges of signal enhancement ratio (SER) values, combined with the spatial pattern of SER images obtained at high-spatial-resolution dynamic contrast-enhanced MR imaging, can be used to help identify those breast tumors at high risk for disease recurrence with high specificity even prior to preoperative chemotherapy.

Invasive Breast Cancer: Predicting Disease Recurrence by Using High-Spatial-Resolution Signal Enhancement Ratio Imaging

Invasive Breast Cancer: Predicting Disease Recurrence by Using High-Spatial-Resolution Signal Enhancement Ratio Imaging
Ka-Loh Li, Savannah C. Partridge, Bonnie N. Joe, Jessica E. Gibbs, Ying Lu, Laura J. Esserman, and Nola M. Hylton
Radiology 2008;248 79-87

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Our study results demonstrate that the size of tumor volume segmented by using set ranges of signal enhancement ratio (SER) values, combined with the spatial pattern of SER images obtained at high-spatial-resolution dynamic contrast-enhanced MR imaging, can be used to help identify those breast tumors at high risk for disease recurrence with high specificity even prior to preoperative chemotherapy.

The Rise and Impending Decline of Screening Mammography

Ferris Hall believes................
Ferris M. Hall
Radiology 2008;247 597-601

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I believe that mammography is going to be replaced by MR imaging as the standard for breast screening, not only in high-risk women but increasingly in those at average risk

Real-time MR-guided Wire Localization of Breast Lesions by Using an Open 1.0-T Imager: Initial Experience

Axel Gossmann, Christopher Bangard, Mathias Warm, Rita K. Schmutzler, Peter Mallmann, and Klaus-Jurgen Lackner
Radiology 2008;247 535-542

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The results of this study show that real-time magnetic resonance (MR) imaging guided wire localization of suspicious breast lesions by using an open 1.0-T imager permits correction of the needle position during placement and reduces the interventional procedure time.

Whole-Body High-Field-Strength (3.0-T) MR Imaging in Clinical Practice

Part I. Technical Considerations and Clinical Applications
Christiane K. Kuhl, Frank Traber, and Hans H. Schild
Radiology 2008;246 675-696

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The higher signal-to-noise ratio at 3.0 T is clearly advantageous and the increased radiofrequency absorption in tissues at higher field strengths is disadvantageous. All other effects, however, can be both advantageous or disadvantageous, depending on the desired image contrast and/or the intended clinical application.

Mammographic, US, and MR Imaging Phenotypes of Familial Breast Cancer

Simone Schrading and Christiane K. Kuhl
Radiology 2008;246 58-70
http://radiology.rsnajnls.org/cgi/content/abstract/246/1/58?etoc

Based on the results obtained in our cohort, we propose that this relatively low sensitivity of MR imaging in women at increased familial risk is due to the fact that these cancers may exhibit unusual imaging features also in breast MR imaging