Evaluation of Clinical Breast MR Imaging Performed with Prototype Computer-aided Diagnosis Breast MR Imaging Workstation: Reader Study

Evaluation of Clinical Breast MR Imaging Performed with Prototype Computer-aided Diagnosis Breast MR Imaging Workstation: Reader Study
Akiko Shimauchi, Maryellen L. Giger, Neha Bhooshan, Li Lan, Lorenzo L. Pesce, John K. Lee, Hiroyuki Abe, and Gillian M. Newstead
Radiology 2011; 258 696-704

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Use of a diagnostic computer aid for dynamic contrast-enhanced MR imaging has the potential to improve radiologists' performance in differentiating between benign and malignant breast lesions

Multicenter, Double-Blind, Randomized, Intraindividual Crossover Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine for Breast MR Imaging (DETECT Trial)

Multicenter, Double-Blind, Randomized, Intraindividual Crossover Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine for Breast MR Imaging (DETECT Trial)
Laura Martincich, Matthieu Faivre-Pierret, Christian M. Zechmann, Stefano Corcione, Harrie C. M. van den Bosch, Wei-Jun Peng, Antonella Petrillo, Katja C. Siegmann, Johannes T. Heverhagen, Pietro Panizza, Hans-Bjorn Gehl, Felix Diekmann, Federica Pediconi, Lin Ma, Fiona J. Gilbert, Francesco Sardanelli, Paolo Belli, Marco Salvatore, Karl-Friedrich Kreitner, Claudia M. Weiss, and Chiara Zuiani
Radiology 2011; 258 396-408

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Gadobenate dimeglumine (0.1 mmol/kg) results in significantly (P [≤ ] . 0003) greater breast cancer detection rate and significantly (P [≤ ] . 0094) better diagnostic performance relative to that achieved with gadopentetate dimeglumine at an equivalent dose

Breast Cancer: Comparative Effectiveness of Positron Emission Mammography and MR Imaging in Presurgical Planning for the Ipsilateral Breast

Breast Cancer: Comparative Effectiveness of Positron Emission Mammography and MR Imaging in Presurgical Planning for the Ipsilateral Breast
Wendie A. Berg, Kathleen S. Madsen, Kathy Schilling, Marie Tartar, Etta D. Pisano, Linda Hovanessian Larsen, Deepa Narayanan, Al Ozonoff, Joel P. Miller, and Judith E. Kalinyak
Radiology 2011; 258 59-72

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Overall, 61 (16%) of 388 participants had an appropriate change in surgical management based on MR findings--more than the 41 (11%) participants with an appropriate change based on positron emission mammography (PEM) findings (P =. 003) and fewer than the 71 (18%) participants with an appropriate change based on combined PEM and MR findings (P =. 004 for comparison with MR imaging alone) ; 25 (6.4%) women had excessive excisions on the basis of MR findings compared with 19 (4.9%) women who had them on the basis of PEM findings (P =. 26) and 32 (8.2%) women who had them after undergoing combined PEM and MR imaging (P =. 023 for comparison with MR imaging alone)

Role of Breast MR Imaging for Predicting Malignancy of Histologically Borderline Lesions Diagnosed at Core Needle Biopsy: Prospective Evaluation

Role of Breast MR Imaging for Predicting Malignancy of Histologically Borderline Lesions Diagnosed at Core Needle Biopsy: Prospective Evaluation
Federica Pediconi, Simona Padula, Valeria Dominelli, MariaLaura Luciani, Marianna Telesca, Valeria Casali, Miles A. Kirchin, Roberto Passariello, and Carlo Catalano
Radiology 2010; 257 653-661

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Correct identification of nonmalignant lesions at MR imaging could direct the patient toward imaging follow-up rather than surgical excision, thereby reducing both patient anxiety and costs related to the surgical procedure as well as avoiding surgical scarring--which potentially could alter the interpretation of subsequent imaging studies

Primary Human Breast Adenocarcinoma: Imaging and Histologic Correlates of Intrinsic Susceptibility-weighted MR Imaging before and during Chemotherapy

Primary Human Breast Adenocarcinoma: Imaging and Histologic Correlates of Intrinsic Susceptibility-weighted MR Imaging before and during Chemotherapy
Sonia P. Li, N. Jane Taylor, Andreas Makris, Mei-Lin W. Ah-See, Mark J. Beresford, J. James Stirling, James A. d'Arcy, David J. Collins, and Anwar R. Padhani
Radiology 2010; 257 643-652

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Intrinsic susceptibility-weighted MR imaging has the ability to provide information about blood volume in patients with primary breast cancer; it may also provide a means with which to evaluate changes in tumor oxygenation in response to chemotherapy

Diffusion-weighted Imaging Improves the Diagnostic Accuracy of Conventional 3.0-T Breast MR Imaging

Diffusion-weighted Imaging Improves the Diagnostic Accuracy of Conventional 3.0-T Breast MR Imaging
Riham H. EI Khouli, Michael A. Jacobs, Sarah D. Mezban, Peng Huang, Ihab R. Kamel, Katarzyna J. Macura, and David A. Bluemke
Radiology 2010;256 64-73

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Adding quantitative diffusion-weighted imaging to the conventional MR imaging protocol resulted in significant diagnostic improvement.

DW imaging with glandular tissue–normalized ADC assessment improves the characterization of breast lesions beyond the characterization achieved with conventional 3D T1-weighted and dynamic contrast-enhanced MR imaging at 3.0 T

Frequency of Malignancy Seen in Probably Benign Lesions at Contrast-enhanced Breast MR Imaging: Findings from ACRIN 6667

Frequency of Malignancy Seen in Probably Benign Lesions at Contrast-enhanced Breast MR Imaging: Findings from ACRIN 6667
Susan P. Weinstein, Lucy G. Hanna, Constantine Gatsonis, Mitchell D. Schnall, Mark A. Rosen, and Constance D. Lehman
Radiology 2010; 255 731-737

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In a multi-institutional study, the frequency of malignancy in MR-detected BI-RADS category 3 lesions was 0.9% (95% confidence interval: 0.02%, 5.14%)

Decrease in Breast Density in the Contralateral Normal Breast of Patients Receiving Neoadjuvant Chemotherapy: MR Imaging Evaluation

Decrease in Breast Density in the Contralateral Normal Breast of Patients Receiving Neoadjuvant Chemotherapy: MR Imaging Evaluation
Jeon-Hor Chen, Ke Nie, Shadfar Bahri, Chieh-Chih Hsu, Fei-Ting Hsu, Han-Ni Shih, Muqing Lin, Orhan Nalcioglu, and Min-Ying Su
Radiology 2010;255 44-52

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By using three-dimensional MR imaging, we have demonstrated that patients receiving chemotherapy showed reduction of breast density and that the effects were significant after initial treatment with one to two cycles of the doxorubicin and cyclophosphamide regimen

Cancerous Breast Lesions on Dynamic Contrast-enhanced MR Images: Computerized Characterization for Image-based Prognostic Markers

Cancerous Breast Lesions on Dynamic Contrast-enhanced MR Images: Computerized Characterization for Image-based Prognostic Markers
Neha Bhooshan, Maryellen L. Giger, Sanaz A. Jansen, Hui Li, Li Lan, and Gillian M. Newstead
Radiology 2010;254 680-690

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Study results show that our MR imaging computer-aided diagnosis algorithm, with use of a combination of computer-extracted MR imaging kinetic and morphologic features, has the potential to be extended to two prognostic tasks: (a) classification of noninvasive (ductal carcinoma in situ) versus invasive (invasive ductal carcinoma [IDC]) lesions and (b) further classification of IDC lesions into lesions with positive lymph nodes (LNs) and lesions with negative LNs.

Identification of Residual Breast Carcinoma Following Neoadjuvant Chemotherapy: Diffusion-weighted Imaging—Comparison with Contrast-enhanced MR Imagin

Identification of Residual Breast Carcinoma Following Neoadjuvant Chemotherapy: Diffusion-weighted Imaging—Comparison with Contrast-enhanced MR Imaging and Pathologic Findings
Reiko Woodhams, Satoko Kakita, Hirofumi Hata, Keiichi Iwabuchi, Masaru Kuranami, Shiva Gautam, Hiroto Hatabu, Shinichi Kan, Carolyn Mountford
Radiology February 2010 254:357-366

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Diffusion-weighted MR imaging without contrast medium may provide diagnostic ability equivalent to that of contrast-enhanced MR imaging in detection of residual breast cancer after neoadjuvant chemotherapy

Reasons Women at Elevated Risk of Breast Cancer Refuse Breast MR Imaging Screening: ACRIN 6666

Reasons Women at Elevated Risk of Breast Cancer Refuse Breast MR Imaging Screening: ACRIN 6666
Wendie A. Berg, Jeffrey D. Blume, Amanda M. Adams, Roberta A. Jong, Richard G. Barr, Daniel E. Lehrer, Etta D. Pisano, W. Phil Evans III, Mary C. Mahoney, Linda Hovanessian Larsen, Glenna J. Gabrielli, and Ellen B. Mendelson
Radiology 2010; 254:79–87
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Of 1215 women with elevated breast cancer risk who could, according to protocol guidelines, undergo breast MR imaging, only 57.9% agreed to participate
Claustrophobia was the most common reason (in 130 [25.4%] of 512 women) given for non-participation

Why Do Purely Intraductal Cancers Enhance on Breast MR Images?
Christiane K. Kuhl
Radiology 2009;253 281-283

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Diagnosis and treatment of high-grade DCIS can be considered primary prevention of high-grade invasive cancer.

Thus, we have reason to assume that screening with MR imaging would offer a mortality benefit that is higher than that achieved with mammographic screening, not only because of the higher overall sensitivity offered by MR imaging but also because of its bias for selectively depicting prognostically relevant disease

On the basis of the results of the animal study performed by Jansen et al and clinical observations, there is compelling evidence to suggest that the imaging phenotype of a ductal carcinoma in situ (DCIS) lesion (its detectability at mammography and MR imaging, specifically the presence or absence of calcifications on mammograms and the presence or absence of calcifications and the degree of their enhancement on MR images) conveys important biologic information that will be useful when guiding DCIS treatment.