Calcifications in Digital Mammographic Screening: Improvement of Early Detection of Invasive Breast Cancers?

Calcifications in Digital Mammographic Screening: Improvement of Early Detection of Invasive Breast Cancers?
Stefanie Weigel, Thomas Decker, Eberhard Korsching, Daniela Hungermann, Werner Böcker, and Walter Heindel
Radiology 2010; 255 738-745

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One-third of malignancies detected on the basis of calcifications only are invasive cancers. They tend to be smaller but not less aggressive than invasive cancers detected on the basis of other features. 

Compared with published results of analog screening, digital screening offers the potential to increase the rate of invasive cancers detected on the basis of calcifications in population-based mammographic screening.  Digital mammography has the potential to increase the rate of invasive cancers detected on the basis of isolated calcifications---cancers that tend to be smaller than those discovered because of other radiologic features

Primary Breast Carcinoma: Association of Mammographic Calcifications with Osteopontin Expression

Primary Breast Carcinoma: Association of Mammographic Calcifications with Osteopontin Expression
Xiao Wang, Lan Chao, Guohui Ma, Liansheng Chen, Guangchao Jin, Mei Hua, Huiping Liu, Aimei Ouyang, and Xiulan Zhang
Radiology 2010 254:69-78
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Compared with osteopontin (OPN)-negative breast cancers, OPN-positive tumors were more likely to have calcifications, to be spiculated, to have pleomorphic calcifications, to be a triple-negative phenotype, and to be associated with axillary lymph node metastasis

Potential Usefulness of Similar Images in the Differential Diagnosis of Clustered Microcalcifications on Mammograms

Potential Usefulness of Similar Images in the Differential Diagnosis of Clustered Microcalcifications on Mammograms
Ryohei Nakayama, Hiroyuki Abe, Junji Shiraishi, and Kunio Doi
Radiology 2009;253 625-631

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The inclusion of similar images can have beneficial effects for many cases in which the status of a lesion is unclear, and it can improve the performance of radiologists in observer studies

Dedicated Breast CT: Initial Clinical Experience

Karen K. Lindfors, John M. Boone, Thomas R. Nelson, Kai Yang, Alexander L. C. Kwan, and DeWitt F. Miller
Radiology 2008;246 725-733

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Masses are significantly more conspicuous on breast CT images compared with screen-film mammograms, but microcalcification lesions are not as well visualized on our early-generation dedicated breast CT images