Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts

Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts
Deborah J. Rhodes, Carrie B. Hruska, Stephen W. Phillips, Dana H. Whaley, and Michael K. O'Connor
Radiology 2011; 258 106-118

Link to Journal

The addition of dedicated dual-head gamma imaging to screening mammography yielded significantly improved sensitivity while maintaining equivalent specificity in women with mammographically dense breasts

Interpretation Time of Computer-aided Detection at Screening Mammography

Interpretation Time of Computer-aided Detection at Screening Mammography
Philip M. Tchou, Tamara Miner Haygood, E. Neely Atkinson, Tanya W. Stephens, Paul L. Davis, Elsa M. Arribas, William R. Geiser, and Gary J. Whitman
Radiology 2010;257 40-46


Link to Journal

The time added to radiologists' interpretations of screening mammograms by the use of computer-aided detection is an important consideration in the assessment of the efficiency of digital mammography interpretation

The additional time required to review CAD images represented a 19% increase in the mean interpretation time without CAD.

CAD requires a considerable time investment for digital screening mammography but may provide less measurable benefits in terms of confidence of the radiologists

Mammographic Features of Breast Cancers at Single Reading with Computer-aided Detection and at Double Reading in a Large Multicenter Prospective Trial of Computer-aided Detection: CADET II

Mammographic Features of Breast Cancers at Single Reading with Computer-aided Detection and at Double Reading in a Large Multicenter Prospective Trial of Computer-aided Detection: CADET II
Jonathan J. James, Fiona J. Gilbert, Matthew G. Wallis, Maureen G. C. Gillan, Susan M. Astley, Caroline R. M. Boggis, Olorunsola F. Agbaje, Adam R. Brentnall, and Stephen W. Duffy
Radiology 2010;256 379-386

Link to Journal

Purpose: To evaluate the mammographic features of breast cancer that favor lesion detection with single reading and computer-aided detection (CAD) or with double reading

Results: A total of 227 cancers were detected in 28 204 women. A total of 170 cases were recalled with both reading regimens. Lesion types were masses (66%), microcalcifications (25%), parenchymal deformities (6%), and asymmetric densities (3%). The ability of the reading regimens to correctly prompt the reader to recall cases varied significantly by lesion type (P < .001). More parenchymal deformities were recalled with double reading, whereas more asymmetric densities were recalled with single reading with CAD. There was no difference in the ability of either reading regimen to prompt the reader to correctly recall masses or microcalcifications. CAD correctly prompted 100% of microcalcifications, 87% of mass lesions, 80% of asymmetric densities, and 50% of parenchymal deformities. CAD correctly marked 93% of spiculated masses compared with 80% of ill-defined masses (P = .054). There was a significant trend for cancers detected with double reading to occur only in women with a denser mammographic background pattern (P = .02). Size had no effect on lesion detection.

Conclusion: Readers using either single reading with CAD or double reading need to be aware of the strengths and weaknesses of reading regimens to avoid missing the more challenging cancer cases

Identifying Minimally Acceptable Interpretive Performance Criteria for Screening Mammography

Identifying Minimally Acceptable Interpretive Performance Criteria for Screening Mammography
Patricia A. Carney, Edward A. Sickles, Barbara S. Monsees, Lawrence W. Bassett, R. James Brenner, Stephen A. Feig, Robert A. Smith, Robert D. Rosenberg, T. Andrew Bogart, Sally Browning, Jane W. Barry, Mary M. Kelly, Khai A. Tran, and Diana L. Miglioretti
Radiology 2010;255 354-361

Link to Journal

Our study contributes important information to existing literature in that we identified six performance cut points important for interpretation of screening mammograms and found that most of the cut points we identified would affect between 20% and 49% of interpreting physicians, who might benefit from additional training to improve their mammogram interpretation skills

NB PERFORMS needed in the USA

Mammographic Appearance Following Accelerated Partial Breast Irradiation by Using MammoSite Brachytherapy

Mammographic Appearance Following Accelerated Partial Breast Irradiation by Using MammoSite Brachytherapy
Haitham M. Ahmed, Pamela J. DiPiro, Phillip M. Devlin, My-Linh Nguyen, and Jennifer R. Bellon
Radiology 2010;255 362-368

Link to Journal

Peak mammographic distortion after MammoSite accelerated partial breast irradiation was shown to occur sooner than that after conventional whole-breast radiation

When Radiologists Perform Best: The Learning Curve in Screening Mammogram Interpretation

When Radiologists Perform Best: The Learning Curve in Screening Mammogram Interpretation
Diana L. Miglioretti, Charlotte C. Gard, Patricia A. Carney, Tracy L. Onega, Diana S. M. Buist, Edward A. Sickles, Karla Kerlikowske, Robert D. Rosenberg, Bonnie C. Yankaskas, Berta M. Geller, and Joann G. Elmore
Radiology 2009;253 632-640

Link to Journal

Radiologists without fellowship training in breast imaging significantly improved in their interpretation of screening mammograms as they gained clinical experience following residency, while radiologists who received fellowship training in breast imaging did not have this learning curve in clinical practice

Influence of E-cadherin Expression on the Mammographic Appearance of Invasive Nonlobular Breast Carcinoma Detected at Screening

Influence of E-cadherin Expression on the Mammographic Appearance of Invasive Nonlobular Breast Carcinoma Detected at Screening
Sarah Doyle, Andrew J. Evans, Emad A. Rakha, Andrew R. Green, and Ian O. Ellis
Radiology 2009;253 51-55
Link to Journal

The high frequency of ill-defined masses and the low frequency of non-comedo microcalcification seen in invasive nonlobular breast cancer with E-cadherin loss are features similar to those seen in a series recording the mammographic appearance of invasive lobular cancer

Cancers in BRCA1 and BRCA2 Carriers and in Women at High Risk for Breast Cancer: MR Imaging and Mammographic Features

Cancers in BRCA1 and BRCA2 Carriers and in Women at High Risk for Breast Cancer: MR Imaging and Mammographic Features
Fiona J. Gilbert, Ruth M. L. Warren, Gek Kwan-Lim, Deborah J. Thompson, Ros A. Eeles, D. Gareth Evans, Martin O. Leach, and For the United Kingdom Magnetic Resonance Imaging in Breast Screening (MARIBS) Study Group
Radiology 2009;252 358-368
Link to Journal

Our review of the images from prior MR imaging examinations shows that the cancers grow in size and that enhancement curves change from type 1 to type 2 or 3 and demonstrate greater signal enhancement over time

Computer-aided Detection Evaluation Methods Are Not Created Equal

Computer-aided Detection Evaluation Methods Are Not Created Equal
Robert M. Nishikawa and Lorenzo L. Pesce
Radiology 2009;251 634-636

Link to Journal

For the evaluation of computer-aided detection, longitudinal studies (historical controls) are inherently different from cross-sectional studies (sequential reading) when cancer detection rate is used as an end point in a screening program

Positive Predictive Value of Specific Mammographic Findings according to Reader and Patient Variables

Positive Predictive Value of Specific Mammographic Findings according to Reader and Patient Variables
Aruna Venkatesan, Philip Chu, Karla Kerlikowske, Edward A. Sickles, and Rebecca Smith-Bindman
Radiology 2009;250 648-657

Link to Journal

Another UCSF classic paper. Asymmetry is the finding with the lowest cancer yield at screening examinations; with asymmetry, invasive cancer (particularly among women younger than 70 years) was infrequently identified and was commonly a false-positive result

Screening Mammography: Does Ethnicity Influence Patient Preferences for Higher Recall Rates Given the Potential for Earlier Detection of Breast Cancer

Screening Mammography: Does Ethnicity Influence Patient Preferences for Higher Recall Rates Given the Potential for Earlier Detection of Breast Cancer?
Nazia F. Jafri, Rama S. Ayyala, Al Ozonoff, Jacqueline Jordan-Gray, and Priscilla J. Slanetz
Radiology 2008;249 785-791

Link to Journal

This study showed that ethnicity influences understanding of mammography, adherence to recall, and preference for early detection

Cutaneous Caves and Subcutaneous Adipose Columns in the Breast: Radiologic-Pathologic Correlation

Cutaneous Caves and Subcutaneous Adipose Columns in the Breast: Radiologic-Pathologic Correlation
Daniel B. Kopans and Jennifer E. Rusby
Radiology 2008;249 779-784

Link to Journal

This report represents the first description of caves in the dermis that contain columns of fat projecting up from the subcutaneous fat into the dermis that also explain the radiolucencies seen on mammograms that were previously incorrectly described as being pores

The "Laboratory" Effect: Comparing Radiologists' Performance and Variability during Prospective Clinical and Laboratory Mammography Interpretations

The "Laboratory" Effect: Comparing Radiologists' Performance and Variability during Prospective Clinical and Laboratory Mammography Interpretations
David Gur, Andriy I. Bandos, Cathy S. Cohen, Christiane M. Hakim, Lara A. Hardesty, Marie A. Ganott, Ronald L. Perrin, William R. Poller, Ratan Shah, Jules H. Sumkin, Luisa P. Wallace, and Howard E. Rockette
Radiology 2008;249 47-53

Link to Journal

When deciding whether to recall a woman for additional diagnostic examinations, experienced radiologists performed significantly better on average and, as important, more consistently in the clinic than in the laboratory when interpreting the same examinations

Premedication to Reduce Discomfort during Screening Mammography

Premedication to Reduce Discomfort during Screening Mammography
Colleen K. Lambertz, Christopher J. Johnson, Paul G. Montgomery, and James R. Maxwell
Radiology 2008;248 765-772

Link to Journal

Premedication with 4% lidocaine gel applied to the skin of the breasts and chest wall significantly reduces discomfort during screening mammography in women who expect greater discomfort.