Axillary Lymph Nodes Suspicious for Breast Cancer Metastasis: Sampling with US-guided 14-Gauge Core-Needle Biopsy--Clinical Experience in 100 Patients

Axillary Lymph Nodes Suspicious for Breast Cancer Metastasis: Sampling with US-guided 14-Gauge Core-Needle Biopsy--Clinical Experience in 100 Patients
Hiroyuki Abe, Robert A. Schmidt, Kirti Kulkarni, Charlene A. Sennett, Jeffrey S. Mueller, and Gillian M. Newstead
Radiology 2008;250 41-49

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Axillary lymph node biopsy performed by using a 14-gauge controllable-action needle with US guidance in patients with breast cancer can yield a high positive result rate with no clinically important complications

Screening Mammography: Does Ethnicity Influence Patient Preferences for Higher Recall Rates Given the Potential for Earlier Detection of Breast Cancer

Screening Mammography: Does Ethnicity Influence Patient Preferences for Higher Recall Rates Given the Potential for Earlier Detection of Breast Cancer?
Nazia F. Jafri, Rama S. Ayyala, Al Ozonoff, Jacqueline Jordan-Gray, and Priscilla J. Slanetz
Radiology 2008;249 785-791

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This study showed that ethnicity influences understanding of mammography, adherence to recall, and preference for early detection

Cutaneous Caves and Subcutaneous Adipose Columns in the Breast: Radiologic-Pathologic Correlation

Cutaneous Caves and Subcutaneous Adipose Columns in the Breast: Radiologic-Pathologic Correlation
Daniel B. Kopans and Jennifer E. Rusby
Radiology 2008;249 779-784

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This report represents the first description of caves in the dermis that contain columns of fat projecting up from the subcutaneous fat into the dermis that also explain the radiolucencies seen on mammograms that were previously incorrectly described as being pores

Tumor Blood Flow with Human Epidermal Growth Factor Receptor 2 Status and Clinicopathologic Findings--Preliminary Results

econvolution-based Dynamic Contrast-enhanced MR Imaging of Breast Tumors: Correlation of Tumor Blood Flow with Human Epidermal Growth Factor Receptor 2 Status and Clinicopathologic Findings--Preliminary Results
Smitha Makkat, Robert Luypaert, Tadeusz Stadnik, Claire Bourgain, Steven Sourbron, Martine Dujardin, Jacques De Greve, and Johan De Mey
Radiology 2008;249 471-482

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To our knowledge, we are the first to examine the association of model-independent MR-derived tumor blood flow, which is a simple and physiologically straightforward parameter, with clinicopathologic characteristics of prognosis, including human epidermal growth factor receptor 2 status

Suspicious Breast Lesions: Assessment of 3D Doppler US Indexes for Classification in a Test Population and Fourfold Cross-Validation Scheme

Suspicious Breast Lesions: Assessment of 3D Doppler US Indexes for Classification in a Test Population and Fourfold Cross-Validation Scheme
Gerald L. LeCarpentier, Marilyn A. Roubidoux, J. Brian Fowlkes, Jochen F. Krucker, Karen A. Hunt, Chintana Paramagul, Timothy D. Johnson, Nancy J. Thorson, Karen D. Engle, and Paul L. Carson
Radiology 2008;249 463-470

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Quantitative Doppler US vascularity measurements considerably contribute to malignant breast tissue identification beyond subjective grayscale valuation alone

Direct MR Galactography: Feasibility Study

Direct MR Galactography: Feasibility Study
Siegfried A. Schwab, Michael Uder, Rudiger Schulz-Wendtland, Werner A. Bautz, Rolf Janka, and Evelyn Wenkel
Radiology 2008;249 54-61

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Direct MR galactography combined with MR imaging may provide more diagnostic information than conventional galactography in patients with pathologic nipple discharge because it can show both ductal morphology and the extent of disease before surgery

The "Laboratory" Effect: Comparing Radiologists' Performance and Variability during Prospective Clinical and Laboratory Mammography Interpretation

The "Laboratory" Effect: Comparing Radiologists' Performance and Variability during Prospective Clinical and Laboratory Mammography Interpretation
David Gur, Andriy I. Bandos, Cathy S. Cohen, Christiane M. Hakim, Lara A. Hardesty, Marie A. Ganott, Ronald L. Perrin, William R. Poller, Ratan Shah, Jules H. Sumkin, Luisa P. Wallace, and Howard E. Rockette
Radiology 2008;249 47-53

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When deciding whether to recall a woman for additional diagnostic examinations, experienced radiologists performed significantly better on average and, as important, more consistently in the clinic than in the laboratory when interpreting the same examinations

Direct MR Galactography: Feasibility Study

Direct MR Galactography: Feasibility Study
Siegfried A. Schwab, Michael Uder, Rudiger Schulz-Wendtland, Werner A.Bautz, Rolf Janka, and Evelyn Wenkel
Radiology 2008;249 54-61

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Direct MR galactography combined with MR imaging may provide more diagnostic information than conventional galactography in patients with
pathologic nipple discharge because it can show both ductal morphology and the extent of disease before surgery.

The "Laboratory" Effect: Comparing Radiologists' Performance and Variability during Prospective Clinical and Laboratory Mammography Interpretations

The "Laboratory" Effect: Comparing Radiologists' Performance and Variability during Prospective Clinical and Laboratory Mammography Interpretations
David Gur, Andriy I. Bandos, Cathy S. Cohen, Christiane M. Hakim, Lara A. Hardesty, Marie A. Ganott, Ronald L. Perrin, William R. Poller, Ratan Shah, Jules H. Sumkin, Luisa P. Wallace, and Howard E. Rockette
Radiology 2008;249 47-53

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When deciding whether to recall a woman for additional diagnostic examinations, experienced radiologists performed significantly better on average and, as important, more consistently in the clinic than in the laboratory when interpreting the same examinations

PET/CT for Monitoring Therapy Response in Breast Cancer Patients with Bone Metastases

PET/CT for Monitoring Therapy Response in Breast Cancer Patients with Bone Metastases
Mohsen Beheshti, Werner Langsteger, and Ukihide Tateishi
Radiology 2008;249 389-390

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Letter to editor

Premedication to Reduce Discomfort during Screening Mammography

Premedication to Reduce Discomfort during Screening Mammography
Colleen K. Lambertz, Christopher J. Johnson, Paul G. Montgomery, and James R. Maxwell
Radiology 2008;248 765-772

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Premedication with 4% lidocaine gel applied to the skin of the breasts and chest wall significantly reduces discomfort during screening mammography in women who expect greater discomfort.

BI-RADS 3, 4, and 5 Lesions: Value of US in Management--Follow-up and Outcome

BI-RADS 3, 4, and 5 Lesions: Value of US in Management--Follow-up and Outcome
Sughra Raza, Sona A. Chikarmane, Sarah S. Neilsen, Lisa M. Zorn, and Robyn L. Birdwell
Radiology 2008;248 773-781

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Our results corroborate those of other studies reporting a negative predictive value of more than 99% in masses at US with recognized benign characteristics, which allows greater confidence in the use of the Breast Imaging Reporting and Data System 3 category for US-determined probably benign masses, whether palpable or not, in a manner akin to the established mammographic paradigm

US-guided 14-gauge Core-Needle Breast Biopsy: Results of a Validation Study in 1352 Cases

US-guided 14-gauge Core-Needle Breast Biopsy: Results of a Validation Study in 1352 Cases
Gerd Schueller, Sylvia Jaromi, Lothar Ponhold, Michael Fuchsjaeger, Mazda Memarsadeghi, Margaretha Rudas, Michael Weber, Laura Liberman, and Thomas H. Helbich
Radiology 2008;248 406-413

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We found agreement among US-guided 14-gauge core-needle breast biopsy results, surgical excision histologic findings, and clinical and imaging follow-up results of 95.8%, with a false-negative rate of 1.6%

Detecting Nonpalpable Recurrent Breast Cancer: The Role of Routine Mammographic Screening of Transverse Rectus Abdominis Myocutaneous Flap Reconstruct

Detecting Nonpalpable Recurrent Breast Cancer: The Role of Routine Mammographic Screening of Transverse Rectus Abdominis Myocutaneous Flap Reconstructions
Janie M. Lee, Dianne Georgian-Smith, G. Scott Gazelle, Elkan F. Halpern, Elizabeth A. Rafferty, Richard H. Moore, Eren D. Yeh, Helen A. D'Alessandro, Rachel A. Hitt, and Daniel B. Kopans
Radiology 2008;248 398-405

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With routine screening mammography, the detection rate of recurrent nonpalpable cancer in transverse rectus abdominis myocutaneous flap breast reconstructions, over a median follow-up period of 4.9 years, was 0%

Breast US Computer-aided Diagnosis Workstation: Performance with a Large Clinical Diagnostic Population

Breast US Computer-aided Diagnosis Workstation: Performance with a Large Clinical Diagnostic Population
Karen Drukker, Nicholas P. Gruszauskas, Charlene A. Sennett, and Maryellen L. Giger
Radiology 2008;248 392-397

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The computer performance was largely unaffected by the inclusion of large numbers of lesions that did not undergo biopsy in the analysis, achieving overall good lesion characterization performance at area under the receiver operating characteristic curve value of 0.90

Primer for residents - Finding Early Invasive Breast Cancers: A Practical Approach

Primer for residents - Finding Early Invasive Breast Cancers: A Practical Approach
Jennifer A. Harvey, Brandi T. Nicholson, and Michael A. Cohen
Radiology 2008;248 61-76

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Virginia resident review on strategies for assessing asymmetries and masses. This is also useful for established breast practitioners

Invasive Breast Cancer: Predicting Disease Recurrence by Using High-Spatial-Resolution Signal Enhancement Ratio Imaging

Invasive Breast Cancer: Predicting Disease Recurrence by Using High-Spatial-Resolution Signal Enhancement Ratio Imaging
Ka-Loh Li, Savannah C. Partridge, Bonnie N. Joe, Jessica E. Gibbs, Ying Lu, Laura J. Esserman, and Nola M. Hylton
Radiology 2008;248 79-87

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Our study results demonstrate that the size of tumor volume segmented by using set ranges of signal enhancement ratio (SER) values, combined with the spatial pattern of SER images obtained at high-spatial-resolution dynamic contrast-enhanced MR imaging, can be used to help identify those breast tumors at high risk for disease recurrence with high specificity even prior to preoperative chemotherapy.

Invasive Breast Cancer: Predicting Disease Recurrence by Using High-Spatial-Resolution Signal Enhancement Ratio Imaging

Invasive Breast Cancer: Predicting Disease Recurrence by Using High-Spatial-Resolution Signal Enhancement Ratio Imaging
Ka-Loh Li, Savannah C. Partridge, Bonnie N. Joe, Jessica E. Gibbs, Ying Lu, Laura J. Esserman, and Nola M. Hylton
Radiology 2008;248 79-87

Link to journal

Our study results demonstrate that the size of tumor volume segmented by using set ranges of signal enhancement ratio (SER) values, combined with the spatial pattern of SER images obtained at high-spatial-resolution dynamic contrast-enhanced MR imaging, can be used to help identify those breast tumors at high risk for disease recurrence with high specificity even prior to preoperative chemotherapy.

Invasive Breast Cancer: Predicting Disease Recurrence by Using High-Spatial-Resolution Signal Enhancement Ratio Imaging

Invasive Breast Cancer: Predicting Disease Recurrence by Using High-Spatial-Resolution Signal Enhancement Ratio Imaging
Ka-Loh Li, Savannah C. Partridge, Bonnie N. Joe, Jessica E. Gibbs, Ying Lu, Laura J. Esserman, and Nola M. Hylton
Radiology 2008;248 79-87

Link to journal

Our study results demonstrate that the size of tumor volume segmented by using set ranges of signal enhancement ratio (SER) values, combined with the spatial pattern of SER images obtained at high-spatial-resolution dynamic contrast-enhanced MR imaging, can be used to help identify those breast tumors at high risk for disease recurrence with high specificity even prior to preoperative chemotherapy.

Breast-specific Gamma Imaging as an Adjunct Imaging Modality for the Diagnosis of Breast Cancer

Rachel F. Brem, Angelique C. Floerke, Jocelyn A. Rapelyea, Christine Teal, Tricia Kelly, and Vivek Mathur
Radiology 2008;247 651-657

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Breast-specific gamma imaging is a promising adjunct imaging modality with high sensitivity and moderate specificity to help detect breast cancers, including subcentimeter (<1>

NOTE: Disclosures

The Rise and Impending Decline of Screening Mammography

Ferris Hall believes................
Ferris M. Hall
Radiology 2008;247 597-601

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I believe that mammography is going to be replaced by MR imaging as the standard for breast screening, not only in high-risk women but increasingly in those at average risk

Real-time MR-guided Wire Localization of Breast Lesions by Using an Open 1.0-T Imager: Initial Experience

Axel Gossmann, Christopher Bangard, Mathias Warm, Rita K. Schmutzler, Peter Mallmann, and Klaus-Jurgen Lackner
Radiology 2008;247 535-542

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The results of this study show that real-time magnetic resonance (MR) imaging guided wire localization of suspicious breast lesions by using an open 1.0-T imager permits correction of the needle position during placement and reduces the interventional procedure time.

Imaging of Lymph Flow in Breast Cancer Patients after Microdose Administration of a Near-Infrared Fluorophore: Feasibility Study

Eva M. Sevick-Muraca, Ruchi Sharma, John C. Rasmussen, Milton V. Marshall, Juliet A. Wendt, Hoang Q. Pham, Elizabeth Bonefas, Jessica P. Houston, Lakshmi Sampath, Kristen E. Adams, Darlene Kay Blanchard, Ronald E. Fisher, Stephen B. Chiang, Richard Elledge, and Michel E. Mawad
Radiology 2008;246 734-741

link

This study demonstrated that noninvasive near-infrared (NIR) optical imaging by using microdose administration of an NIR fluorophore is feasible in humans.

Dedicated Breast CT: Initial Clinical Experience

Karen K. Lindfors, John M. Boone, Thomas R. Nelson, Kai Yang, Alexander L. C. Kwan, and DeWitt F. Miller
Radiology 2008;246 725-733

link

Masses are significantly more conspicuous on breast CT images compared with screen-film mammograms, but microcalcification lesions are not as well visualized on our early-generation dedicated breast CT images

Whole-Body High-Field-Strength (3.0-T) MR Imaging in Clinical Practice

Part I. Technical Considerations and Clinical Applications
Christiane K. Kuhl, Frank Traber, and Hans H. Schild
Radiology 2008;246 675-696

link

The higher signal-to-noise ratio at 3.0 T is clearly advantageous and the increased radiofrequency absorption in tissues at higher field strengths is disadvantageous. All other effects, however, can be both advantageous or disadvantageous, depending on the desired image contrast and/or the intended clinical application.

Diagnostic Accuracy of Digital versus Film Mammography

Diagnostic Accuracy of Digital versus Film Mammography: Exploratory Analysis of Selected Population Subgroups in DMIST
Etta D. Pisano, R. Edward Hendrick, Martin J. Yaffe, Janet K. Baum, Suddhasatta Acharyya, Jean B. Cormack, Lucy A. Hanna, Emily F. Conant, Laurie L. Fajardo, Lawrence W. Bassett, Carl J. D'Orsi, Roberta A. Jong, Murray Rebner, Anna N. A. Tosteson, Constantine A. Gatsonis For the DMIST Investigators Group
Radiology 2008;246 376-383
http://radiology.rsnajnls.org/cgi/content/abstract/246/2/376?etoc

The results reported here corroborate the trend in favor of improved diagnostic accuracy of digital mammography over film for pre- and perimenopausal women younger than 50 years with dense breasts

Estrogen Receptor-Negative Invasive Breast Cancer: Imaging Features

Estrogen Receptor-Negative Invasive Breast Cancer: Imaging Features of Tumors with and without Human Epidermal Growth Factor Receptor Type 2 Over-expression
Yingbing Wang, Debra M. Ikeda, Balasubramanian Narasimhan, Teri A.Longacre, Richard J. Bleicher, Sunita Pal, Roger J. Jackman, and Stefanie S. Jeffrey
Radiology 2008;246 367-375
http://radiology.rsnajnls.org/cgi/content/abstract/246/2/367?etoc

We found that lesion margin and presence of calcifications on images, as well as cancer stage at diagnosis, are significantly associated with human epidermal growth factor receptor type 2 status in patients with estrogen receptor negative breast cancer

Axillary Lymph Nodes: US-guided Fine-Needle Aspiration for Initial Staging of Breast Cancer Correlation with Primary Tumor Size

Susan L. Koelliker, Maureen A. Chung, Martha B. Mainiero, Margaret M. Steinhoff, and Blake Cady
Radiology 2007;246 81-89
http://radiology.rsnajnls.org/cgi/content/abstract/246/1/81?etoc

US-guided fine-needle aspiration is useful in the initial axillary staging of breast cancer; the sensitivity of the technique increases with increasing tumor size

Computer-aided Detection in Full-Field Digital Mammography: Sensitivity and Reproducibility in Serial Examinations

Seung Ja Kim, Woo Kyung Moon, Nariya Cho, Joo Hee Cha, Sun Mi Kim, and Jung-Gi Im
Radiology 2007;246 71-80
http://radiology.rsnajnls.org/cgi/content/abstract/246/1/71?etoc

When a computer-aided detection system was applied to initial and short-term follow-up digital mammograms, sensitivities were, respectively, 91% and 89% for masses and 100% and 100% for microcalcifications; overall false-positive mark rates were 0.29 mark per image and 0.27 mark per image at initial and follow-up digital mammography, respectively

Mammographic, US, and MR Imaging Phenotypes of Familial Breast Cancer

Simone Schrading and Christiane K. Kuhl
Radiology 2008;246 58-70
http://radiology.rsnajnls.org/cgi/content/abstract/246/1/58?etoc

Based on the results obtained in our cohort, we propose that this relatively low sensitivity of MR imaging in women at increased familial risk is due to the fact that these cancers may exhibit unusual imaging features also in breast MR imaging