Tumor Angiogenesis Change Estimated by Using Diffuse Optical Spectroscopic Tomography: Demonstrated Correlation in Women Undergoing Neoadjuvant Chemotherapy for Invasive Breast Cancer?

Tumor Angiogenesis Change Estimated by Using Diffuse Optical Spectroscopic Tomography: Demonstrated Correlation in Women Undergoing Neoadjuvant Chemotherapy for Invasive Breast Cancer?
Marius G. Pakalniskis, Wendy A. Wells, Mary C. Schwab, Heather M. Froehlich, Shudong Jiang, Zhongze Li, Tor D. Tosteson, Steven P. Poplack, Peter A. Kaufman, Brian W. Pogue, and Keith D. Paulsen
Radiology 2011; 259 365-374

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This study results show a correlation between changes in total tissue hemoglobin at diffuse optical spectroscopic tomography and tumor angiogenesis and demonstrate how this noninvasive modality might allow individualization and optimization of neoadjuvant chemotherapy regimens.

Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer

Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer
Yanming Yu, Quan Jiang, Yanwei Miao, Jun Li, Shanglian Bao, Haoyu Wang, Chunxue Wu, Xiaoying Wang, Jiong Zhu, Yi Zhong, E. Mark Haacke, and Jiani Hu
Radiology 2010;257 47-55

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A quantitative dynamic contrast-enhanced MR imaging method has been developed to assess treatment response to neoadjuvant chemotherapy in patients with breast cancer by using standard clinical dynamic contrast-enhanced MR imaging data without measuring either arterial input function or baseline T1.

Results of the simulation study demonstrate that the T1-FCM method appears to be relatively insensitive to noisy dynamic contrast-enhanced MR imaging data. This method could prove useful in the evaluation of breast cancer therapy

Diffusion-weighted MR Imaging: Pretreatment Prediction of Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer

Diffusion-weighted MR Imaging: Pretreatment Prediction of Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer
Sang Hee Park, Woo Kyung Moon, Nariya Cho, In Chan Song, Jung Min Chang, In-Ae Park, Wonshik Han, and Dong-Young Noh
Radiology 2010;257 56-63


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Our results show that in patients with breast cancer, the pretreatment apparent diffusion coefficients of patients who responded to neoadjuvant chemotherapy are significantly lower than those of patients who did not respond to neoadjuvant chemotherapy.

Patients with breast cancer and a low pretreatment ADC tended to respond better to chemotherapy. Prediction of response to neoadjuvant chemotherapy with DW MR imaging might help physicians individualize treatments and avoid ineffective chemotherapy