Primary Human Breast Adenocarcinoma: Imaging and Histologic Correlates of Intrinsic Susceptibility-weighted MR Imaging before and during Chemotherapy

Primary Human Breast Adenocarcinoma: Imaging and Histologic Correlates of Intrinsic Susceptibility-weighted MR Imaging before and during Chemotherapy
Sonia P. Li, N. Jane Taylor, Andreas Makris, Mei-Lin W. Ah-See, Mark J. Beresford, J. James Stirling, James A. d'Arcy, David J. Collins, and Anwar R. Padhani
Radiology 2010; 257 643-652

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Intrinsic susceptibility-weighted MR imaging has the ability to provide information about blood volume in patients with primary breast cancer; it may also provide a means with which to evaluate changes in tumor oxygenation in response to chemotherapy

Can Preoperative Axillary US Help Exclude N2 and N3 Metastatic Breast Cancer?

Can Preoperative Axillary US Help Exclude N2 and N3 Metastatic Breast Cancer?
Colleen H. Neal, Caroline P. Daly, Alexis V. Nees, and Mark A. Helvie
Radiology 2010; 257 335-341

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Axillary US is a valuable modality for evaluating the preoperative status of the axilla and provides a noninvasive means with which to accurately exclude advanced axillary metastatic disease for 96% of patients with invasive ductal carcinoma

Interpretation Time of Computer-aided Detection at Screening Mammography

Interpretation Time of Computer-aided Detection at Screening Mammography
Philip M. Tchou, Tamara Miner Haygood, E. Neely Atkinson, Tanya W. Stephens, Paul L. Davis, Elsa M. Arribas, William R. Geiser, and Gary J. Whitman
Radiology 2010;257 40-46


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The time added to radiologists' interpretations of screening mammograms by the use of computer-aided detection is an important consideration in the assessment of the efficiency of digital mammography interpretation

The additional time required to review CAD images represented a 19% increase in the mean interpretation time without CAD.

CAD requires a considerable time investment for digital screening mammography but may provide less measurable benefits in terms of confidence of the radiologists

Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer

Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer
Yanming Yu, Quan Jiang, Yanwei Miao, Jun Li, Shanglian Bao, Haoyu Wang, Chunxue Wu, Xiaoying Wang, Jiong Zhu, Yi Zhong, E. Mark Haacke, and Jiani Hu
Radiology 2010;257 47-55

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A quantitative dynamic contrast-enhanced MR imaging method has been developed to assess treatment response to neoadjuvant chemotherapy in patients with breast cancer by using standard clinical dynamic contrast-enhanced MR imaging data without measuring either arterial input function or baseline T1.

Results of the simulation study demonstrate that the T1-FCM method appears to be relatively insensitive to noisy dynamic contrast-enhanced MR imaging data. This method could prove useful in the evaluation of breast cancer therapy

Diffusion-weighted MR Imaging: Pretreatment Prediction of Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer

Diffusion-weighted MR Imaging: Pretreatment Prediction of Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer
Sang Hee Park, Woo Kyung Moon, Nariya Cho, In Chan Song, Jung Min Chang, In-Ae Park, Wonshik Han, and Dong-Young Noh
Radiology 2010;257 56-63


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Our results show that in patients with breast cancer, the pretreatment apparent diffusion coefficients of patients who responded to neoadjuvant chemotherapy are significantly lower than those of patients who did not respond to neoadjuvant chemotherapy.

Patients with breast cancer and a low pretreatment ADC tended to respond better to chemotherapy. Prediction of response to neoadjuvant chemotherapy with DW MR imaging might help physicians individualize treatments and avoid ineffective chemotherapy

Short-term Follow-up Recommendations after Preoperative Breast MR Assessment for Breast Cancer Diagnosis: Are We Lacking a Rational Basis?

Short-term Follow-up Recommendations after Preoperative Breast MR Assessment for Breast Cancer Diagnosis: Are We Lacking a Rational Basis?
R. James Brenner
Radiology 2010;257 18-21

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Unless clinical studies demonstrate previously unrecognized changes on serial MR imaging studies under such circumstances which likely are not based on the mechanisms of actions described earlier, the recommendation for short-term follow-up MR imaging after preoperative assessment should be reconsidered

Contrast-enhanced Dedicated Breast CT: Initial Clinical Experience

Contrast-enhanced Dedicated Breast CT: Initial Clinical Experience
Nicolas D. Prionas, Karen K. Lindfors, Shonket Ray, Shih-Ying Huang, Laurel A. Beckett, Wayne L. Monsky, and John M. Boone
Radiology 2010;256 714-723

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Conspicuity of malignant breast masses at contrast-enhanced breast CT is significantly better than that at mammography or unenhanced breast CT, whereas conspicuity of lesions associated with malignant calcifications is better at contrast-enhanced breast CT than at unenhanced breast CT and is similar at contrast-enhanced breast CT and mammography

Learning Points:

Malignant mass lesions are significantly more conspicuous than benign lesions at contrast-enhanced dedicated breast CT when compared with mammography and unenhanced breast CT (P < .001 for each comparison).

Visualization of malignant calcifications (malignant lesions manifested mammographically as microcalcifications only) at contrast-enhanced breast CT is improved over that at unenhanced breast CT (P < .001) and is similar to that at mammography (P = .64).

Malignant breast lesions enhance by a mean of 38 HU more than do benign lesions (P < .001), and receiver operating characteristic curve analysis yields an area under the receiver operating characteristic curve of 0.876