Breast Cancer: Early and Late Fluorescence Near-Infrared Imaging with Indocyanine Green: A Preliminary Study
Alexander Poellinger, Susen Burock, Dirk Grosenick, Axel Hagen, Lutz Ludemann, Felix Diekmann, Florian Engelken, Rainer Macdonald, Herbert Rinneberg, and Peter-Michael Schlag
Radiology 2011; 258 409-416
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By capitalizing on the extravasation of indocyanine green (ICG) through the wall of tumorous vessels and consequently using late-fluorescence mammograms, we were able to achieve far more pronounced contrast between the tumorous and healthy background tissue (mean contrast value, 0.64) compared with this contrast on images acquired during or shortly after the administration of ICG (mean contrast value, 0.25)
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