Interpretation Time of Computer-aided Detection at Screening Mammography
Philip M. Tchou, Tamara Miner Haygood, E. Neely Atkinson, Tanya W. Stephens, Paul L. Davis, Elsa M. Arribas, William R. Geiser, and Gary J. Whitman
Radiology 2010;257 40-46
Link to Journal
The time added to radiologists' interpretations of screening mammograms by the use of computer-aided detection is an important consideration in the assessment of the efficiency of digital mammography interpretation
The additional time required to review CAD images represented a 19% increase in the mean interpretation time without CAD.
CAD requires a considerable time investment for digital screening mammography but may provide less measurable benefits in terms of confidence of the radiologists
Friday, 17 September 2010
Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer
Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer
Yanming Yu, Quan Jiang, Yanwei Miao, Jun Li, Shanglian Bao, Haoyu Wang, Chunxue Wu, Xiaoying Wang, Jiong Zhu, Yi Zhong, E. Mark Haacke, and Jiani Hu
Radiology 2010;257 47-55
Link to Journal
A quantitative dynamic contrast-enhanced MR imaging method has been developed to assess treatment response to neoadjuvant chemotherapy in patients with breast cancer by using standard clinical dynamic contrast-enhanced MR imaging data without measuring either arterial input function or baseline T1.
Results of the simulation study demonstrate that the T1-FCM method appears to be relatively insensitive to noisy dynamic contrast-enhanced MR imaging data. This method could prove useful in the evaluation of breast cancer therapy
Yanming Yu, Quan Jiang, Yanwei Miao, Jun Li, Shanglian Bao, Haoyu Wang, Chunxue Wu, Xiaoying Wang, Jiong Zhu, Yi Zhong, E. Mark Haacke, and Jiani Hu
Radiology 2010;257 47-55
Link to Journal
A quantitative dynamic contrast-enhanced MR imaging method has been developed to assess treatment response to neoadjuvant chemotherapy in patients with breast cancer by using standard clinical dynamic contrast-enhanced MR imaging data without measuring either arterial input function or baseline T1.
Results of the simulation study demonstrate that the T1-FCM method appears to be relatively insensitive to noisy dynamic contrast-enhanced MR imaging data. This method could prove useful in the evaluation of breast cancer therapy
Diffusion-weighted MR Imaging: Pretreatment Prediction of Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer
Diffusion-weighted MR Imaging: Pretreatment Prediction of Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer
Sang Hee Park, Woo Kyung Moon, Nariya Cho, In Chan Song, Jung Min Chang, In-Ae Park, Wonshik Han, and Dong-Young Noh
Radiology 2010;257 56-63
Link to Journal
Our results show that in patients with breast cancer, the pretreatment apparent diffusion coefficients of patients who responded to neoadjuvant chemotherapy are significantly lower than those of patients who did not respond to neoadjuvant chemotherapy.
Patients with breast cancer and a low pretreatment ADC tended to respond better to chemotherapy. Prediction of response to neoadjuvant chemotherapy with DW MR imaging might help physicians individualize treatments and avoid ineffective chemotherapy
Sang Hee Park, Woo Kyung Moon, Nariya Cho, In Chan Song, Jung Min Chang, In-Ae Park, Wonshik Han, and Dong-Young Noh
Radiology 2010;257 56-63
Link to Journal
Our results show that in patients with breast cancer, the pretreatment apparent diffusion coefficients of patients who responded to neoadjuvant chemotherapy are significantly lower than those of patients who did not respond to neoadjuvant chemotherapy.
Patients with breast cancer and a low pretreatment ADC tended to respond better to chemotherapy. Prediction of response to neoadjuvant chemotherapy with DW MR imaging might help physicians individualize treatments and avoid ineffective chemotherapy
Short-term Follow-up Recommendations after Preoperative Breast MR Assessment for Breast Cancer Diagnosis: Are We Lacking a Rational Basis?
Short-term Follow-up Recommendations after Preoperative Breast MR Assessment for Breast Cancer Diagnosis: Are We Lacking a Rational Basis?
R. James Brenner
Radiology 2010;257 18-21
Link to Journal
Unless clinical studies demonstrate previously unrecognized changes on serial MR imaging studies under such circumstances which likely are not based on the mechanisms of actions described earlier, the recommendation for short-term follow-up MR imaging after preoperative assessment should be reconsidered
R. James Brenner
Radiology 2010;257 18-21
Link to Journal
Unless clinical studies demonstrate previously unrecognized changes on serial MR imaging studies under such circumstances which likely are not based on the mechanisms of actions described earlier, the recommendation for short-term follow-up MR imaging after preoperative assessment should be reconsidered
Wednesday, 18 August 2010
Contrast-enhanced Dedicated Breast CT: Initial Clinical Experience
Contrast-enhanced Dedicated Breast CT: Initial Clinical Experience
Nicolas D. Prionas, Karen K. Lindfors, Shonket Ray, Shih-Ying Huang, Laurel A. Beckett, Wayne L. Monsky, and John M. Boone
Radiology 2010;256 714-723
Link to Journal
Conspicuity of malignant breast masses at contrast-enhanced breast CT is significantly better than that at mammography or unenhanced breast CT, whereas conspicuity of lesions associated with malignant calcifications is better at contrast-enhanced breast CT than at unenhanced breast CT and is similar at contrast-enhanced breast CT and mammography
Learning Points:
Malignant mass lesions are significantly more conspicuous than benign lesions at contrast-enhanced dedicated breast CT when compared with mammography and unenhanced breast CT (P < .001 for each comparison).
Visualization of malignant calcifications (malignant lesions manifested mammographically as microcalcifications only) at contrast-enhanced breast CT is improved over that at unenhanced breast CT (P < .001) and is similar to that at mammography (P = .64).
Malignant breast lesions enhance by a mean of 38 HU more than do benign lesions (P < .001), and receiver operating characteristic curve analysis yields an area under the receiver operating characteristic curve of 0.876
Nicolas D. Prionas, Karen K. Lindfors, Shonket Ray, Shih-Ying Huang, Laurel A. Beckett, Wayne L. Monsky, and John M. Boone
Radiology 2010;256 714-723
Link to Journal
Conspicuity of malignant breast masses at contrast-enhanced breast CT is significantly better than that at mammography or unenhanced breast CT, whereas conspicuity of lesions associated with malignant calcifications is better at contrast-enhanced breast CT than at unenhanced breast CT and is similar at contrast-enhanced breast CT and mammography
Learning Points:
Malignant mass lesions are significantly more conspicuous than benign lesions at contrast-enhanced dedicated breast CT when compared with mammography and unenhanced breast CT (P < .001 for each comparison).
Visualization of malignant calcifications (malignant lesions manifested mammographically as microcalcifications only) at contrast-enhanced breast CT is improved over that at unenhanced breast CT (P < .001) and is similar to that at mammography (P = .64).
Malignant breast lesions enhance by a mean of 38 HU more than do benign lesions (P < .001), and receiver operating characteristic curve analysis yields an area under the receiver operating characteristic curve of 0.876
Friday, 23 July 2010
Mammographic Features of Breast Cancers at Single Reading with Computer-aided Detection and at Double Reading in a Large Multicenter Prospective Trial of Computer-aided Detection: CADET II
Mammographic Features of Breast Cancers at Single Reading with Computer-aided Detection and at Double Reading in a Large Multicenter Prospective Trial of Computer-aided Detection: CADET II
Jonathan J. James, Fiona J. Gilbert, Matthew G. Wallis, Maureen G. C. Gillan, Susan M. Astley, Caroline R. M. Boggis, Olorunsola F. Agbaje, Adam R. Brentnall, and Stephen W. Duffy
Radiology 2010;256 379-386
Link to Journal
Purpose: To evaluate the mammographic features of breast cancer that favor lesion detection with single reading and computer-aided detection (CAD) or with double reading
Results: A total of 227 cancers were detected in 28 204 women. A total of 170 cases were recalled with both reading regimens. Lesion types were masses (66%), microcalcifications (25%), parenchymal deformities (6%), and asymmetric densities (3%). The ability of the reading regimens to correctly prompt the reader to recall cases varied significantly by lesion type (P < .001). More parenchymal deformities were recalled with double reading, whereas more asymmetric densities were recalled with single reading with CAD. There was no difference in the ability of either reading regimen to prompt the reader to correctly recall masses or microcalcifications. CAD correctly prompted 100% of microcalcifications, 87% of mass lesions, 80% of asymmetric densities, and 50% of parenchymal deformities. CAD correctly marked 93% of spiculated masses compared with 80% of ill-defined masses (P = .054). There was a significant trend for cancers detected with double reading to occur only in women with a denser mammographic background pattern (P = .02). Size had no effect on lesion detection.
Conclusion: Readers using either single reading with CAD or double reading need to be aware of the strengths and weaknesses of reading regimens to avoid missing the more challenging cancer cases
Jonathan J. James, Fiona J. Gilbert, Matthew G. Wallis, Maureen G. C. Gillan, Susan M. Astley, Caroline R. M. Boggis, Olorunsola F. Agbaje, Adam R. Brentnall, and Stephen W. Duffy
Radiology 2010;256 379-386
Link to Journal
Purpose: To evaluate the mammographic features of breast cancer that favor lesion detection with single reading and computer-aided detection (CAD) or with double reading
Results: A total of 227 cancers were detected in 28 204 women. A total of 170 cases were recalled with both reading regimens. Lesion types were masses (66%), microcalcifications (25%), parenchymal deformities (6%), and asymmetric densities (3%). The ability of the reading regimens to correctly prompt the reader to recall cases varied significantly by lesion type (P < .001). More parenchymal deformities were recalled with double reading, whereas more asymmetric densities were recalled with single reading with CAD. There was no difference in the ability of either reading regimen to prompt the reader to correctly recall masses or microcalcifications. CAD correctly prompted 100% of microcalcifications, 87% of mass lesions, 80% of asymmetric densities, and 50% of parenchymal deformities. CAD correctly marked 93% of spiculated masses compared with 80% of ill-defined masses (P = .054). There was a significant trend for cancers detected with double reading to occur only in women with a denser mammographic background pattern (P = .02). Size had no effect on lesion detection.
Conclusion: Readers using either single reading with CAD or double reading need to be aware of the strengths and weaknesses of reading regimens to avoid missing the more challenging cancer cases
Early-Stage Invasive Breast Cancers: Potential Role of Optical Tomography with US Localization in Assisting Diagnosis
Early-Stage Invasive Breast Cancers: Potential Role of Optical Tomography with US Localization in Assisting Diagnosis
Quing Zhu, Poornima U. Hegde, Andrew Ricci, Jr, Mark Kane, Edward B. Cronin, Yasaman Ardeshirpour, Chen Xu, Andres Aguirre, Scott H. Kurtzman, Peter J. Deckers, and Susan H. Tannenbaum
Radiology 2010;256 367-378
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Purpose: To investigate the potential role of optical tomography in the near-infrared (NIR) spectrum with ultrasonographic (US) localization as a means of differentiating early-stage cancers from benign lesions of the breast.
We showed that intrinsic angiogenesis (tHb - total hemoglobin concentration) contrast imaged by using the NIR technique with US holds promise as an adjunct to mammography and US for distinguishing early-stage invasive breast cancers from benign lesions
Quing Zhu, Poornima U. Hegde, Andrew Ricci, Jr, Mark Kane, Edward B. Cronin, Yasaman Ardeshirpour, Chen Xu, Andres Aguirre, Scott H. Kurtzman, Peter J. Deckers, and Susan H. Tannenbaum
Radiology 2010;256 367-378
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Purpose: To investigate the potential role of optical tomography in the near-infrared (NIR) spectrum with ultrasonographic (US) localization as a means of differentiating early-stage cancers from benign lesions of the breast.
We showed that intrinsic angiogenesis (tHb - total hemoglobin concentration) contrast imaged by using the NIR technique with US holds promise as an adjunct to mammography and US for distinguishing early-stage invasive breast cancers from benign lesions
Multiparametric Imaging of Tumor Response to Therapy
Multiparametric Imaging of Tumor Response to Therapy
Anwar R. Padhani and Kenneth A. Miles
Radiology 2010;256 348-364
Link to Journal
By combining quantitative biomarker data from a number of imaging techniques one may begin to understand how novel therapies affect tumor cells and tissue microenvironments
Anwar R. Padhani and Kenneth A. Miles
Radiology 2010;256 348-364
Link to Journal
By combining quantitative biomarker data from a number of imaging techniques one may begin to understand how novel therapies affect tumor cells and tissue microenvironments
Wednesday, 23 June 2010
Time Trends in Radiologists’ Interpretive Performance at Screening Mammography from the Community-based Breast Cancer Surveillance Consortium, 1996–2004
Time Trends in Radiologists’ Interpretive Performance at Screening Mammography from the Community-based Breast Cancer Surveillance Consortium, 1996–2004
Laura E. Ichikawa, William E. Barlow, Melissa L. Anderson, Stephen H. Taplin, Berta M. Geller, R. James Brenner for the National Cancer Institute–sponsored Breast Cancer Surveillance Consortium
Radiology 2010;256 74-82
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We found an overall improvement in radiologists’ interpretive performance at subsequent screening mammography, 1996–2004, in a large national sample of women aged 40–79 years, with increases in both sensitivity and recall rate and a decrease in specificity
Recall rate and sensitivity for screening mammograms increased, whereas specificity decreased from 1996 to 2004 among women with a prior mammogram. This trend remained after accounting for risk factors. The net effect was an improvement in overall discrimination, a measure of the probability that a mammogram with cancer in the follow-up period has a higher Breast Imaging Reporting and Data System assessment category than does a mammogram without cancer in the follow-up period
Laura E. Ichikawa, William E. Barlow, Melissa L. Anderson, Stephen H. Taplin, Berta M. Geller, R. James Brenner for the National Cancer Institute–sponsored Breast Cancer Surveillance Consortium
Radiology 2010;256 74-82
Link to Journal
We found an overall improvement in radiologists’ interpretive performance at subsequent screening mammography, 1996–2004, in a large national sample of women aged 40–79 years, with increases in both sensitivity and recall rate and a decrease in specificity
Recall rate and sensitivity for screening mammograms increased, whereas specificity decreased from 1996 to 2004 among women with a prior mammogram. This trend remained after accounting for risk factors. The net effect was an improvement in overall discrimination, a measure of the probability that a mammogram with cancer in the follow-up period has a higher Breast Imaging Reporting and Data System assessment category than does a mammogram without cancer in the follow-up period
Diffusion-weighted Imaging Improves the Diagnostic Accuracy of Conventional 3.0-T Breast MR Imaging
Diffusion-weighted Imaging Improves the Diagnostic Accuracy of Conventional 3.0-T Breast MR Imaging
Riham H. EI Khouli, Michael A. Jacobs, Sarah D. Mezban, Peng Huang, Ihab R. Kamel, Katarzyna J. Macura, and David A. Bluemke
Radiology 2010;256 64-73
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Adding quantitative diffusion-weighted imaging to the conventional MR imaging protocol resulted in significant diagnostic improvement.
DW imaging with glandular tissue–normalized ADC assessment improves the characterization of breast lesions beyond the characterization achieved with conventional 3D T1-weighted and dynamic contrast-enhanced MR imaging at 3.0 T
Riham H. EI Khouli, Michael A. Jacobs, Sarah D. Mezban, Peng Huang, Ihab R. Kamel, Katarzyna J. Macura, and David A. Bluemke
Radiology 2010;256 64-73
Link to Journal
Adding quantitative diffusion-weighted imaging to the conventional MR imaging protocol resulted in significant diagnostic improvement.
DW imaging with glandular tissue–normalized ADC assessment improves the characterization of breast lesions beyond the characterization achieved with conventional 3D T1-weighted and dynamic contrast-enhanced MR imaging at 3.0 T
BI-RADS Data Should Not Be Used to Estimate ROC Curves
BI-RADS Data Should Not Be Used to Estimate ROC Curves
Yulei Jiang and Charles E. Metz
Radiology 2010;256 29-31
Link to Journal
After applauding the recent trend of employing receiver operating characteristic (ROC) analysis to measure diagnostic performance in large clinical studies, we discuss why Breast Imaging Reporting and Data System data should not be used to estimate ROC curves in screening mammography
However, to truly realize the benefit of this assessment method, one must estimate ROC curves appropriately, addressing additional issues that arise as ROC analysis migrates from the laboratory to the clinic. Hypothetical perturbation of results from a recent study indicates that BI-RADS data do not provide a reliable basis for estimating ROC curves in screening mammography. Although we appreciate the potential benefit of—and therefore, the motivation for—estimating ROC curves from existing clinical cases in which BI-RADS assessments are recorded, we must recommend caution until an approach is found that overcomes the problems we have identified here. Any future methodologic innovations in prospective clinical study design that will allow diagnostic confidence to be reported on a true ordinal scale without introducing additional bias are welcome and should be exploited to help address these problems
Yulei Jiang and Charles E. Metz
Radiology 2010;256 29-31
Link to Journal
After applauding the recent trend of employing receiver operating characteristic (ROC) analysis to measure diagnostic performance in large clinical studies, we discuss why Breast Imaging Reporting and Data System data should not be used to estimate ROC curves in screening mammography
However, to truly realize the benefit of this assessment method, one must estimate ROC curves appropriately, addressing additional issues that arise as ROC analysis migrates from the laboratory to the clinic. Hypothetical perturbation of results from a recent study indicates that BI-RADS data do not provide a reliable basis for estimating ROC curves in screening mammography. Although we appreciate the potential benefit of—and therefore, the motivation for—estimating ROC curves from existing clinical cases in which BI-RADS assessments are recorded, we must recommend caution until an approach is found that overcomes the problems we have identified here. Any future methodologic innovations in prospective clinical study design that will allow diagnostic confidence to be reported on a true ordinal scale without introducing additional bias are welcome and should be exploited to help address these problems
The 2009 U.S. Preventive Services Task Force Guidelines Ignore Important Scientific Evidence and Should Be Revised or Withdrawn
The 2009 U.S. Preventive Services Task Force Guidelines Ignore Important Scientific Evidence and Should Be Revised or Withdrawn
Daniel B. Kopans
Radiology 2010;256 15-20
Link to Journal
The task force should know that their guidelines, and not revisionist statements, will be used to dissuade, if not prevent, women from undergoing mammographic screening
The USPSTF comprised individuals who had no direct expertise in mammographic screening. The members chosen to review mammographic screening are, by charter, “internists, pediatricians, family physicians, gynecologists/obstetricians, and nurses”.
Based on the oversights listed above, it seems to me that they did not understand the fundamentals of the randomized controlled trials of screening. They ignored direct data from screened populations in favor of computer models that were selected for them and decided to deprive women of access to screening because the task force decided that the anxiety caused by a recall from screening (most of which are easily resolved by extra mammographic views or US) was too much for women to tolerate
Daniel B. Kopans
Radiology 2010;256 15-20
Link to Journal
The task force should know that their guidelines, and not revisionist statements, will be used to dissuade, if not prevent, women from undergoing mammographic screening
The USPSTF comprised individuals who had no direct expertise in mammographic screening. The members chosen to review mammographic screening are, by charter, “internists, pediatricians, family physicians, gynecologists/obstetricians, and nurses”.
Based on the oversights listed above, it seems to me that they did not understand the fundamentals of the randomized controlled trials of screening. They ignored direct data from screened populations in favor of computer models that were selected for them and decided to deprive women of access to screening because the task force decided that the anxiety caused by a recall from screening (most of which are easily resolved by extra mammographic views or US) was too much for women to tolerate
Breast Cancer Screening: From Science to Recommendation
Breast Cancer Screening: From Science to Recommendation
Diana B. Petitti, Ned Calonge, Michael L. LeFevre, Bernadette Mazurek Melnyk, Timothy J. Wilt, J. Sanford Schwartz for the U.S. Preventive Services Task Force
Radiology 2010;256 8-14
Link to Journal
Further progress in reducing breast cancer morbidity and mortality will require a better understanding of methods for primary prevention, more effective therapy, and improved diagnostic tests that reduce false-positives and identify women with lesions likely to benefit from intervention
This is a response by the US Preventative Services Task Force to some of the criticisms leveled at their recent published guidelines (particularly the under 50's). Dan Kopans robust reply follows
Diana B. Petitti, Ned Calonge, Michael L. LeFevre, Bernadette Mazurek Melnyk, Timothy J. Wilt, J. Sanford Schwartz for the U.S. Preventive Services Task Force
Radiology 2010;256 8-14
Link to Journal
Further progress in reducing breast cancer morbidity and mortality will require a better understanding of methods for primary prevention, more effective therapy, and improved diagnostic tests that reduce false-positives and identify women with lesions likely to benefit from intervention
This is a response by the US Preventative Services Task Force to some of the criticisms leveled at their recent published guidelines (particularly the under 50's). Dan Kopans robust reply follows
Computer-aided US Diagnosis of Breast Lesions by Using Cell-based Contour Grouping
Computer-aided US Diagnosis of Breast Lesions by Using Cell-based Contour Grouping
Jie-Zhi Cheng, Yi-Hong Chou, Chiun-Sheng Huang, Yeun-Chung Chang, Chui-Mei Tiu, Kuei-Wu Chen, and Chung-Ming Chen
Radiology 2010; 255 746-754
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We present an efficient computer-aided diagnostic algorithm with an automatic segmentation approach where the lesion boundaries determined by using the cell-based contour grouping (CBCG) algorithms were shown to be close to the manually delineated boundaries, and the morphologic features determined from these CBCG-generated boundaries gave a high differentiation performance
Jie-Zhi Cheng, Yi-Hong Chou, Chiun-Sheng Huang, Yeun-Chung Chang, Chui-Mei Tiu, Kuei-Wu Chen, and Chung-Ming Chen
Radiology 2010; 255 746-754
Link to Journal
We present an efficient computer-aided diagnostic algorithm with an automatic segmentation approach where the lesion boundaries determined by using the cell-based contour grouping (CBCG) algorithms were shown to be close to the manually delineated boundaries, and the morphologic features determined from these CBCG-generated boundaries gave a high differentiation performance
Calcifications in Digital Mammographic Screening: Improvement of Early Detection of Invasive Breast Cancers?
Calcifications in Digital Mammographic Screening: Improvement of Early Detection of Invasive Breast Cancers?
Stefanie Weigel, Thomas Decker, Eberhard Korsching, Daniela Hungermann, Werner Böcker, and Walter Heindel
Radiology 2010; 255 738-745
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One-third of malignancies detected on the basis of calcifications only are invasive cancers. They tend to be smaller but not less aggressive than invasive cancers detected on the basis of other features.
Compared with published results of analog screening, digital screening offers the potential to increase the rate of invasive cancers detected on the basis of calcifications in population-based mammographic screening. Digital mammography has the potential to increase the rate of invasive cancers detected on the basis of isolated calcifications---cancers that tend to be smaller than those discovered because of other radiologic features
Stefanie Weigel, Thomas Decker, Eberhard Korsching, Daniela Hungermann, Werner Böcker, and Walter Heindel
Radiology 2010; 255 738-745
Link to Journal
One-third of malignancies detected on the basis of calcifications only are invasive cancers. They tend to be smaller but not less aggressive than invasive cancers detected on the basis of other features.
Compared with published results of analog screening, digital screening offers the potential to increase the rate of invasive cancers detected on the basis of calcifications in population-based mammographic screening. Digital mammography has the potential to increase the rate of invasive cancers detected on the basis of isolated calcifications---cancers that tend to be smaller than those discovered because of other radiologic features
Frequency of Malignancy Seen in Probably Benign Lesions at Contrast-enhanced Breast MR Imaging: Findings from ACRIN 6667
Frequency of Malignancy Seen in Probably Benign Lesions at Contrast-enhanced Breast MR Imaging: Findings from ACRIN 6667
Susan P. Weinstein, Lucy G. Hanna, Constantine Gatsonis, Mitchell D. Schnall, Mark A. Rosen, and Constance D. Lehman
Radiology 2010; 255 731-737
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In a multi-institutional study, the frequency of malignancy in MR-detected BI-RADS category 3 lesions was 0.9% (95% confidence interval: 0.02%, 5.14%)
Susan P. Weinstein, Lucy G. Hanna, Constantine Gatsonis, Mitchell D. Schnall, Mark A. Rosen, and Constance D. Lehman
Radiology 2010; 255 731-737
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In a multi-institutional study, the frequency of malignancy in MR-detected BI-RADS category 3 lesions was 0.9% (95% confidence interval: 0.02%, 5.14%)
Risk of Upgrade of Atypical Ductal Hyperplasia after Stereotactic Breast Biopsy: Effects of Number of Foci and Complete Removal of Calcifications
Risk of Upgrade of Atypical Ductal Hyperplasia after Stereotactic Breast Biopsy: Effects of Number of Foci and Complete Removal of Calcifications
Jennifer R. Kohr, Peter R. Eby, Kimberly H. Allison, Wendy B. DeMartini, Robert L. Gutierrez, Sue Peacock, and Constance D. Lehman
Radiology 2010; 255 723-730
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Ultimately, despite the theoretically improved accuracy of 9- and 11-gauge vacuum-assisted breast biopsy needles and the risk stratification performed on the basis of histopathologic and mammographic criteria, we were unable to identify a subpopulation of patients with atypical ductal hyperplasia who could safely avoid surgical excision
The upgrade rate is significantly higher when ADH involves at least three foci. Surgical excision is recommended even when ADH involves fewer than three foci and all mammographic calcifications have been removed, because the upgrade rate is 12%
Jennifer R. Kohr, Peter R. Eby, Kimberly H. Allison, Wendy B. DeMartini, Robert L. Gutierrez, Sue Peacock, and Constance D. Lehman
Radiology 2010; 255 723-730
Link to Journal
Ultimately, despite the theoretically improved accuracy of 9- and 11-gauge vacuum-assisted breast biopsy needles and the risk stratification performed on the basis of histopathologic and mammographic criteria, we were unable to identify a subpopulation of patients with atypical ductal hyperplasia who could safely avoid surgical excision
The upgrade rate is significantly higher when ADH involves at least three foci. Surgical excision is recommended even when ADH involves fewer than three foci and all mammographic calcifications have been removed, because the upgrade rate is 12%
Wednesday, 28 April 2010
More Mammography Muddle: Emotions, Politics, Science, Costs, and Polarization
More Mammography Muddle: Emotions, Politics, Science, Costs, and Polarization
Leonard Berlin and Ferris M. Hall
Radiology 2010;255 311-316
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Controversies regarding medical screening and many other cost-benefit health care decisions are increasingly societal issues rather than purely scientific ones, and therefore, open-minded public discussion and education should be welcome
Leonard Berlin and Ferris M. Hall
Radiology 2010;255 311-316
Link to Journal
Controversies regarding medical screening and many other cost-benefit health care decisions are increasingly societal issues rather than purely scientific ones, and therefore, open-minded public discussion and education should be welcome
Identifying Minimally Acceptable Interpretive Performance Criteria for Screening Mammography
Identifying Minimally Acceptable Interpretive Performance Criteria for Screening Mammography
Patricia A. Carney, Edward A. Sickles, Barbara S. Monsees, Lawrence W. Bassett, R. James Brenner, Stephen A. Feig, Robert A. Smith, Robert D. Rosenberg, T. Andrew Bogart, Sally Browning, Jane W. Barry, Mary M. Kelly, Khai A. Tran, and Diana L. Miglioretti
Radiology 2010;255 354-361
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Our study contributes important information to existing literature in that we identified six performance cut points important for interpretation of screening mammograms and found that most of the cut points we identified would affect between 20% and 49% of interpreting physicians, who might benefit from additional training to improve their mammogram interpretation skills
NB PERFORMS needed in the USA
Patricia A. Carney, Edward A. Sickles, Barbara S. Monsees, Lawrence W. Bassett, R. James Brenner, Stephen A. Feig, Robert A. Smith, Robert D. Rosenberg, T. Andrew Bogart, Sally Browning, Jane W. Barry, Mary M. Kelly, Khai A. Tran, and Diana L. Miglioretti
Radiology 2010;255 354-361
Link to Journal
Our study contributes important information to existing literature in that we identified six performance cut points important for interpretation of screening mammograms and found that most of the cut points we identified would affect between 20% and 49% of interpreting physicians, who might benefit from additional training to improve their mammogram interpretation skills
NB PERFORMS needed in the USA
Mammographic Appearance Following Accelerated Partial Breast Irradiation by Using MammoSite Brachytherapy
Mammographic Appearance Following Accelerated Partial Breast Irradiation by Using MammoSite Brachytherapy
Haitham M. Ahmed, Pamela J. DiPiro, Phillip M. Devlin, My-Linh Nguyen, and Jennifer R. Bellon
Radiology 2010;255 362-368
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Peak mammographic distortion after MammoSite accelerated partial breast irradiation was shown to occur sooner than that after conventional whole-breast radiation
Haitham M. Ahmed, Pamela J. DiPiro, Phillip M. Devlin, My-Linh Nguyen, and Jennifer R. Bellon
Radiology 2010;255 362-368
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Peak mammographic distortion after MammoSite accelerated partial breast irradiation was shown to occur sooner than that after conventional whole-breast radiation
Monday, 22 March 2010
Decrease in Breast Density in the Contralateral Normal Breast of Patients Receiving Neoadjuvant Chemotherapy: MR Imaging Evaluation
Decrease in Breast Density in the Contralateral Normal Breast of Patients Receiving Neoadjuvant Chemotherapy: MR Imaging Evaluation
Jeon-Hor Chen, Ke Nie, Shadfar Bahri, Chieh-Chih Hsu, Fei-Ting Hsu, Han-Ni Shih, Muqing Lin, Orhan Nalcioglu, and Min-Ying Su
Radiology 2010;255 44-52
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By using three-dimensional MR imaging, we have demonstrated that patients receiving chemotherapy showed reduction of breast density and that the effects were significant after initial treatment with one to two cycles of the doxorubicin and cyclophosphamide regimen
Jeon-Hor Chen, Ke Nie, Shadfar Bahri, Chieh-Chih Hsu, Fei-Ting Hsu, Han-Ni Shih, Muqing Lin, Orhan Nalcioglu, and Min-Ying Su
Radiology 2010;255 44-52
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By using three-dimensional MR imaging, we have demonstrated that patients receiving chemotherapy showed reduction of breast density and that the effects were significant after initial treatment with one to two cycles of the doxorubicin and cyclophosphamide regimen
Saturday, 13 March 2010
Axillary Lymph Node Metastasis: CA-15-3 and Carcinoembryonic Antigen Concentrations in Fine-Needle Aspirates for Preoperative Diagnosis in Patients wi
Axillary Lymph Node Metastasis: CA-15-3 and Carcinoembryonic Antigen Concentrations in Fine-Needle Aspirates for Preoperative Diagnosis in Patients with Breast Cancer
Min Jung Kim, Byeong-Woo Park, Jong-Baeck Lim, Hyon-Suk Kim, Jin Young Kwak, Soo Jin Kim, Sung Hee Park, Yu-Mee Sohn, Hee Jung Moon, and Eun-Kyung Kim
Radiology 2010;254 691-697
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The mean fine-needle aspiration (FNA) concentrations of carcinoembryonic antigen (CEA) and the breast cancer antigen CA-15-3 in metastatic axillary lymph nodes (ALNs) were higher (both P = .02) than those in nonmetastatic ALNs, and the sensitivity of FNA cytology combined with FNA concentrations of CA-15-3 and CEA was higher (P = .01) than that of FNA cytology alone.
Min Jung Kim, Byeong-Woo Park, Jong-Baeck Lim, Hyon-Suk Kim, Jin Young Kwak, Soo Jin Kim, Sung Hee Park, Yu-Mee Sohn, Hee Jung Moon, and Eun-Kyung Kim
Radiology 2010;254 691-697
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The mean fine-needle aspiration (FNA) concentrations of carcinoembryonic antigen (CEA) and the breast cancer antigen CA-15-3 in metastatic axillary lymph nodes (ALNs) were higher (both P = .02) than those in nonmetastatic ALNs, and the sensitivity of FNA cytology combined with FNA concentrations of CA-15-3 and CEA was higher (P = .01) than that of FNA cytology alone.
Cancerous Breast Lesions on Dynamic Contrast-enhanced MR Images: Computerized Characterization for Image-based Prognostic Markers
Cancerous Breast Lesions on Dynamic Contrast-enhanced MR Images: Computerized Characterization for Image-based Prognostic Markers
Neha Bhooshan, Maryellen L. Giger, Sanaz A. Jansen, Hui Li, Li Lan, and Gillian M. Newstead
Radiology 2010;254 680-690
Link to Journal
Study results show that our MR imaging computer-aided diagnosis algorithm, with use of a combination of computer-extracted MR imaging kinetic and morphologic features, has the potential to be extended to two prognostic tasks: (a) classification of noninvasive (ductal carcinoma in situ) versus invasive (invasive ductal carcinoma [IDC]) lesions and (b) further classification of IDC lesions into lesions with positive lymph nodes (LNs) and lesions with negative LNs.
Neha Bhooshan, Maryellen L. Giger, Sanaz A. Jansen, Hui Li, Li Lan, and Gillian M. Newstead
Radiology 2010;254 680-690
Link to Journal
Study results show that our MR imaging computer-aided diagnosis algorithm, with use of a combination of computer-extracted MR imaging kinetic and morphologic features, has the potential to be extended to two prognostic tasks: (a) classification of noninvasive (ductal carcinoma in situ) versus invasive (invasive ductal carcinoma [IDC]) lesions and (b) further classification of IDC lesions into lesions with positive lymph nodes (LNs) and lesions with negative LNs.
Identification, Biopsy, and Treatment of Poorly Understood Premalignant, in Situ, and Indolent Low-Grade Cancers: Are We Becoming Victims of Our Own S
Identification, Biopsy, and Treatment of Poorly Understood Premalignant, in Situ, and Indolent Low-Grade Cancers: Are We Becoming Victims of Our Own Success?
Ferris M. Hall
Radiology 2010;254 655-659
Link to Journal
Imagers are increasingly detecting and performing percutaneous biopsies on borderline, preinvasive, or low-grade cancers that were heretofore rarely identified and that may never progress to meaningful disease.
Ferris M. Hall
Radiology 2010;254 655-659
Link to Journal
Imagers are increasingly detecting and performing percutaneous biopsies on borderline, preinvasive, or low-grade cancers that were heretofore rarely identified and that may never progress to meaningful disease.
Thursday, 21 January 2010
Breast Arterial Calcifications on Mammograms Do Not Predict Coronary Heart Disease at Coronary Angiograph
Breast Arterial Calcifications on Mammograms Do Not Predict Coronary Heart Disease at Coronary Angiography
Radiology February 2010 254:367-373
Mohammad H. Zgheib, Shalom S. Buchbinder, Nidal Abi Rafeh, Marwan Elya, Carolyn Raia, Kathleen Ahern, Marianne C. Smith, Thomas Costantino, Michael J. Flory, James C. Lafferty, Mario R. Castellanos
Link to Journal
Among the women who underwent coronary angiography, the frequency of breast arterial calcification in the women with coronary heart disease (CHD) was not significantly different from that in those without CHD, even when CHD severity and location were considered
Radiology February 2010 254:367-373
Mohammad H. Zgheib, Shalom S. Buchbinder, Nidal Abi Rafeh, Marwan Elya, Carolyn Raia, Kathleen Ahern, Marianne C. Smith, Thomas Costantino, Michael J. Flory, James C. Lafferty, Mario R. Castellanos
Link to Journal
Among the women who underwent coronary angiography, the frequency of breast arterial calcification in the women with coronary heart disease (CHD) was not significantly different from that in those without CHD, even when CHD severity and location were considered
Identification of Residual Breast Carcinoma Following Neoadjuvant Chemotherapy: Diffusion-weighted Imaging—Comparison with Contrast-enhanced MR Imagin
Identification of Residual Breast Carcinoma Following Neoadjuvant Chemotherapy: Diffusion-weighted Imaging—Comparison with Contrast-enhanced MR Imaging and Pathologic Findings
Reiko Woodhams, Satoko Kakita, Hirofumi Hata, Keiichi Iwabuchi, Masaru Kuranami, Shiva Gautam, Hiroto Hatabu, Shinichi Kan, Carolyn Mountford
Radiology February 2010 254:357-366
Link to Journal
Diffusion-weighted MR imaging without contrast medium may provide diagnostic ability equivalent to that of contrast-enhanced MR imaging in detection of residual breast cancer after neoadjuvant chemotherapy
Reiko Woodhams, Satoko Kakita, Hirofumi Hata, Keiichi Iwabuchi, Masaru Kuranami, Shiva Gautam, Hiroto Hatabu, Shinichi Kan, Carolyn Mountford
Radiology February 2010 254:357-366
Link to Journal
Diffusion-weighted MR imaging without contrast medium may provide diagnostic ability equivalent to that of contrast-enhanced MR imaging in detection of residual breast cancer after neoadjuvant chemotherapy
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